Growth Hormone plays a vital role in cell reproduction, growth stimulation, and cell regeneration for humans and other animals. Human Growth Hormones are very important for human development, especially for children. The journey of the bio-synthetic Humatrope before it was approved and used for human benefit is not easy. Actually, the source of Growth Hormone before was undeniably unbelievable. But thanks to those hardworking biochemists and medical workers for their effort to create a certain remedy concerning growth failures.
In connection with Growth Hormone(GH), there is a very restricted clinical study of growth hormone recorded in the late 1950’s derived from the rhesus macaque a known old world monkey, by John C. Beck, and his colleagues in Montreal. Based on their analysis published in 1957, which was led to a 3-year-old boy, they found out that there was a substantial surge in the urinary excretion of aldosterone through both phases of management of GH coming from the monkey. But the study about the Growth Hormone derived from the monkey is unsuccessful because there is no change in the glucose tolerance of the body on the fifth day.
On the other hand, the identification and later production of growth hormone is connected with Chinese-born US Biochemist, Cho Hao Li. Li spent his whole academic profession studying the pituitary-gland hormones. While the pioneer of the first use of recombinant growth hormone for human therapy is the biotechnology corporation, Genentech in 1981.
It is said that before the mid-1980’s, the main source of Human Growth Hormones or HGH was the pituitary glands of corpses. It sounds gross and creepy but that time, it was the only way to obtain it.
In 1985, the cadaver somatropin was drawn out of the market by the Food and Drug Administration (FDA) when they found out that it can cause a rare disease called CJD or the Creutzfeldt-Jakob syndrome also called when human is infected as the disease “mad-cow”. This alarming illness is a deteriorating illness that is deadly and typically incurable. Due to the discovery of this kind of disease, the HGH (Human Growth Hormone) replacement therapy seemed to have met its dead end.
Nevertheless, medical technology has evolved rapidly since those days. In 1985, Eli Lilly & company synthesized a new improved Bio-Synthetic Version Humatrope. The US Food and Drug Administration (FDA) approved Humatrope on March 8, 1987, and eventually permitted by (PMDA) on October 1, 2008. Humatrope is a replacement therapy for the long-term treatment of children having a growth failure due to the insufficient secretion of normal endogenic growth hormone.
What is Humatrope?
Humatrope is the exact DNA match to the human body’s 191 amino acids that originated in the pituitary gland. Thus, it makes it as the standard measurement of all the other synthetic forms of Human Growth Hormones or HGH for Sale. It has a molecular weight of about 22, 125 daltons and it is considered as the perfect substitute for the growth hormones naturally made by our body. Humatrope is made in a strain of the bacteria Escherichia coli and has been modified by the addition of genes for human growth hormone. Prior to the discovery of growth hormone protein as an identical match of the human DNA, it was eventually produced by drug laboratories in commercial quantities.
In addition, Humatrope is said to be a recombinant HGH that has a direct metabolic and tissue effects. This includes the stimulation of lipolysis, stimulation of hepatic glucose output, and the stimulation of chondrocyte differentiation. It is also used to treat children who are abnormally undersized or growing very slowly. There are many reasons why this condition happens to the children. One reason is that they don’t produce enough GH on their own. Another reason is that they possibly have a Turner Syndrome or a condition which a female has a completely missing X chromosome. Furthermore, this condition among children may be triggered by being born way smaller than usual after a week of pregnancy and unable to catch up in stature by two to four years of age. The children may also have a short stature homeobox or SHOX deficiency as well as idiopathic short stature.
Aside from treating children with abnormal growth pattern, Humatrope is also used to treat adults suffers growth hormone deficiencies and can also decrease body fats. This deficiency in adults may start either in childhood or in adulthood due to hypothalamic disease, radiation therapy, pituitary disease, surgery or trauma. Humatrope also has an anabolic property or agent that is why it has been used by competitors in sports since 1982 to enhance their performance. But it was currently disapproved by the FDA (Food and Drugs Administration). Moreover, Growth Hormone has been studied for use in raising livestock efficiently in industrial agriculture. But the use of Growth Hormone for livestock needs several efforts before obtaining governmental approval. The use of Growth Hormone for livestock production has been controversial ever since. Prior to this, the FDA (Food and Drug Administration) in the United States only approved the use of bovine somatotropin, a specific form of Growth Hormone found in a cow.
Just like any other bio-synthetic hormone products, Humatrope is administered with the help of injections. A doctor may decide to give the shot or injection intramuscularly (injected in the muscles) or do it subcutaneously (injected under the skin). The Hormones are made available by vials and cartridges. The cartridges vary in sizes ranging from 6 mg, 12 mg, and 24mg. On the other hand, a vial kit can contain a 5 ml of a diluent vial or a 5 mg of Humatrope vial. Some other Humatrope is also packed in a HumatroPen that has a hidden needle cover, in order for it to be easily injected.
During this time, the Humatrope (the brand name of Somatropin), is one of the most efficient forms of Growth Hormone (GH) in the world. The discovery and refinement of somatropin may not be easy but it’s worth it because it helps a lot of people and animals.